ea0059s6.3 | The most important nine months; impact of maternal health | SFEBES2018
Yam Kit-yi
, Naninck Eva
, Abbink Maralinde
, Ruigrok Silvie
, Reemst Kitty
, Lucassen Paul
, Kotah Janssen
, Aniko Korosi
Early-life stress (ES) is associated with increased vulnerability to cognitive impairments as well as metabolic disorders like obesity later in life. We investigate the role of a synergistic effect of stress, metabolic factors, nutrition and the neuroimmune system in this early-life induced programming. We use an established model of chronic ES and expose mice to limited nesting and bedding material during first postnatal week and study the central and peripheral systems under...